The international team of researchers identified the potential microbial guilty, which is behind the alarming rise of the rectal cancer: a bacterial toxin called Colibactin. Also Read Symptoms of the rectal cancer: What do you need to know
Scientists say that the exposure to colibactin in early childhood affects the clear genetic signature on the DNA of the cells of the colon, which can significantly increase the risk of cancer of the rectum under the age of 50.
Conclusions of the study:
The study was headed by an international team of researchers led by the University of California San Diego.
It was made by certain strains of the Escherichia coli, which are in the colon and rectum, coliba – toxin capable of changing DNA.
A new study, published on April 23 in Nature, analyzed 981 rectum cancer genomes in patients with early and late -starting disease in 11 countries with different levels of rectal cancer.
The data shows that Colibactin leaves behind certain DNA mutations, which were 3.3 times more often in cases of early start (in particular in adults up to 40) than those who have been diagnosed after 70 years.
These mutation models were also particularly common in high -speed countries.
“These mutation models are a kind of historical record in the genome, and they indicate the impact of early life of calibactin as a driving disease early,” said the senior author of the study Lyudmil Alexandrov, Professor in Shu-Chien-Gene, Bioenginery Department and Molecular Medicine. Also Read Cancer rectum: Doctor explains early warning signs, we should not ignore
Despite the fact that previous studies, including preliminary works in the Alexandrov laboratory, found mutations associated with colibactin, about 10 to 15 percent of all cases of rectal cancer, these studies were either concentrated in cases with a late start or did not distinguish early and late disease.
This last study is the first to demonstrate significant enrichment of mutations associated with colibactin, specifically in cases of early start.
The consequences of sober. Once the elderly disease was considered to be the rectal cancer increases in at least 27 countries.
Over the last 20 years, its frequency in adults to 50 has doubled every decade. Also Read Doctors warn: liver cancer can suffer you in the 20s. That’s what to watch in your diet
When the current trends are ongoing, by 2030, young adult rectal cancer will become the main cause of cancer -related death among young people.
By this time, the reasons for this strain remained unknown.
Young people diagnosed with rectal cancer often have no family history and little risk factors such as obesity or hypertension.
This caused the assumptions about the potential hidden environmental or microbial impact of the new study directly investigating.
Note for readers: This article is intended only for information purposes rather than to replace professional medical advice. Always seek the advice of a doctor with any medical issues.
