Wait what? Tin peanuts treat Peanut allergies? This may seem counterinth, but the new innovative study suggests that. In the first clinical trial of this kind, scientists have checked whether adult allergy to peanuts desensitize with peanuts.
Adult Peanut Immunotherapy (GUPI) lawsuts led by London and Guy and Saint -Tomas NHS Foundation, a peanut allergy to the allergen, which in this case is a peanut. Published in Allergy, the lawsuit demonstrated a great success with two -thirds of test subjects consuming the equivalent of five peanuts without responding. This is the first study in adults with serious allergies to check if you can safely tolerate daily doses of peanuts taken under strict supervision.
This method is known as oral immunotherapy, has seen success in infants and children around the world. New conclusions of the first trial in adults.
“Constant fear of life-threatening reactions for life lays a heavy load on people with peanuts allergies. The only way to control peanuts is strictly avoidance and treatment of allergic reactions, including adrenaline. Although peanuts are known to be effective in children. Summit interventions are increased by 100 measured embroidery by 100 measured heights of 100 -meter -fledged trial.
21 adults between the ages of 18 and 40 with clinically diagnosed peanuts were included in the II phase test. They confirmed allergies with the help of a skin test, blood test, and then with oral food. In the clinical setting, the participants received the first dose of 0.8 mg of peanuts mixed with food, then 1.5 mg after 30 minutes, then 3 mg after another 30 minutes. Those who could carry 1.5 mg or 3 mg of peanut flour gave a daily dose of the house for 2 weeks. This is the equivalent of 0.5-1% of the whole peanuts. They were controlled at two-week intervals and received more peanut protein under the dose, increasing from 6 mg (about 1/40th of peanuts) to 1G (four whole peanuts).
Participants who were moderate up to 50-100 mg of peanut protein were switched to eating a whole peanut, peanut butter or peanuts, with the first dose under the control of the clinical team.
Participants continued the daily dosage at least three months before the trial, as well as the possibility to continue after the study. The data showed that 67% of participants were able to consume at least 1.4 g of peanut protein, which is equivalent to five peanuts, without reaction. The trial participants were asked to consume peanuts every day at home to remain desensitized.
“We are very satisfied with the results. The level of efficiency generally corresponds to peanut oral immunotherapy in children. The next stage of the study will be confirmation of this in a greater test, as well as to determine the group of adult patients who would most likely use immunotherapy parameters, and to find out whether it can lead to long-term tolerance.
Leading author’s allergy specialist nutritionist Khan Hunter from Guy and NHS St. Thomas Foundation noted: “Life with peanut allergies is a huge load due to the need for constant vigilance, and the risk of accidental effects. Imunotherapy and food fear also decreased.
Chris, 28, a participant of the trial, which was diagnosed with peanuts as a child, said: “I am so proud that he was a participant of this lawsuit, and so glad to say that I was allergic to peanuts, but because of this lawsuit, it is no longer worrying. Not concerned with my life, and I was connected with the fact that I could even be dangerous.
