Cancer treatment has gone a long way. As a result of therapies such as chemotherapy, radiation, target drugs and immunotherapy, modern medicine offers various treatment options that can significantly improve survival as well as quality of life for many patients. However, for some rare and aggressive cancers, effective treatments remain limited. According to the study, the initially developed medicine designed to treat Pinworm infections may offer a new line of protection against one of the aggressive cancers. The new study, headed by the Arizona Cancer Center, has shown that Pinworm has the potential for treating aggressive skin cancer. The conclusions were published in the journal clinical study.Attachment of medicines for the treatment of skin cancer
Merkel cell carcinoma is an aggressive form of skin cancer. It is a rare but fast-growing neuroendocrine cancer, which is three to five times more likely than melanoma to be deadly. The speed of response to modern therapies, such as surgery, radiation and immunotherapy, which leads to the need for effective and widely suitable therapy.“The Merkel’s step is increasing in the disease. Although this is a rare type of cancer, it mimics many properties that have other rivers,” said the senior author of the Cancer Center and the Associate Professor of the College of Science in a statement. Researchers have found that the overall attack of the drug could stop and change the growth of cancer in the cellular carcinoma of Merkel. Medicines – Pyrvinium Pamoate, which was approved by the Power Office and Medicines (FDA) in 1955 for the treatment of Stemalets. It has been shown that this drug has antitumor potential in several different cancers, including breast rivers, rectum, pancreas and bladder. However, this is the first time it was studied in the Merkel cell carcinoma models.Exploration
(Pic courtesy: istock)
To understand whether the treatment medicine is effective in the treatment of Merkel cell carcinoma, the researchers checked it in laboratory models. They found that pyrvinium pamoate inhibits the growth of cancer cells and canceled neuroendocrine features of cancer. This medicine helped to reduce the growth of the tumor in the mouse models of the cellular carcinoma of Merkel.
“This is a hypothesis, but some people believe that the reason when the anti -parasitic agent may be effective against cancer, is that the tumors are slightly similar to parasites in our body. Parasites and tumors must develop ways to use scarce resources from the host to feed themselves and provide unlimited multiplication. If the paths they hijacked to feed themselves are the same, you will be lucky, and you have a type of tumor that can succumb to the murder of these anti -parasitic drugs, “Padi said.
Researchers have decided to check pyrvinium pamoate after detecting the WNT signal path as one of the molecular mechanisms that move the transition of normal cells to the cell carcinoma. Pyrvinium Pamoate – Famous WNT path inhibitor. While Pinworm has shown the promise of treating aggressive forms of cancer, researchers added that additional studies needed to optimize treatment protocols to develop pyrvinium pamoate as a clinically useful medication for the Merkel cell carcinoma.
