Main protein defined for the treatment of Alzheimer’s disease: study

A team of researchers at Cologne University made an important contribution to understanding the role of Tau in Alzheimer’s disease.

Using plucotte stem cells caused by man (IPSC), the international team has demonstrated that a certain variant of Tau protein, known as 1n4r -isoff, indicates a harmful effect of a protein that knocks down brain cells.

The study was headed by Dr. Hans Zerpel of the Human Genet Institute, who is also the leader of the Career Program (CAP) Center Cologne Medicine (CMMC) Cologne University and Cologne University Hospital. Also Read Blows Alzheimer by -Men: That’s why it’s worse than you think

When a person suffers from Alzheimer’s disease, some proteins accumulate in brain cells, forming lumps that limit the normal cell function or even force the cell to die.

Conclusions of the study:

Dr. Account and Dr. Earth used the latest methods, such as editing Crispr/Cas9 genes and images in live cells in plucotte stem cells (IPSC) to demonstrate that Isoff 1n4R causes pathological impact on the cell. IPSC is a person’s stem cells formed from other cells.

For example, skin cells can be reprogrammed into IPSC and then turn into brain cells (neurons). The researchers checked different forms of Tau protein, expressing them specifically in nerve cells. This allowed them to analyze how each iso -protein affect the cell.

According to Dr. Sarah Buchholtz, the first author of the study, “this study is a significant progress in helping us understand the mechanisms of Alzheimer’s disease. Determining 1N4R Tau as a key protein, we found a potential new target for future therapies.” Also Read Alzheimer’s disease: The mystery of the dying cells is solved

The interdisciplinary approach of the study not only helps to better understand Alzheimer’s disease, but also demonstrates the importance of human cell models in neurodegenerative studies. Further studies are necessary to translate the results of this study into clinical application, in particular, to check the results in adequate animal models and to develop specific therapeutic drugs that will intervene in this process.

Note for readers: This article is intended only for information purposes rather than to replace professional medical advice. Always seek the advice of a doctor with any medical issues.