According to the World Health Organization (WHO), 15 million people suffer from stroke worldwide. Of these, 5 million die, and 5 million remained finally disabled. What makes a stroke extremely dangerous is that it can be deadly or leave a person with disabilities. The latter significantly reduces the quality of life. Currently, scientists have developed a new drug that can significantly reduce brain damage caused by strokes. Yes, that’s right!Scientists at the University of Cambridge have developed a drug that can reduce brain damage caused by strokes by 60%. The results of the study are published in cardiovascular studies.
What is a stroke
The impact occurs when the blood to the brain is blocked or suddenly there is a sudden bleeding. There are two types of beats.
- Ischemic stroke
- Hemorrhagic stroke
Ischemic stroke is a stroke that occurs when bleeding to the brain is blocked. Hemorrhagic strokes are those that occur when the blood vessels are torn and go into the brain. Ischemic stroke is the most common type, which is approximately 87% of all beats. The impact can be either deadly or leave devastating consequences. Every fourth person will have a blow to life. The first few hours after the stroke are crucial. This is a time when the blood clot must be removed quickly so that the oxygen supply to the brain can be restored; Otherwise, the brain tissue begins to die. Currently, mechanical thrombectomy is gold standard treatment. However, the results are still bad, less than every 10 patients leaving the hospital without neurological disorders.
The new drug offers a promise to reduce brain damage in survivors
(Pic courtesy: istock)
Cambridge scientists have developed and tested a new drug in mice that can reduce brain damage when blood flow is restored after a stroke.“A stroke is a destructive disease. Even for those who survive, there is a significant risk of brain damage, which can lead to a disability and a huge effect on human life. But in terms of treatment, as soon as a stroke has occurred, we only have limited options,” the department of medicine at the University of Cambridge. Mechanical thrombectomy is a small invasive medical procedure when a thin pipe, known as a catheter, is introduced into the blood vessel, often through the groin or hand. This is directed to blood clots, where it is removed by a tiny device, restoring normal bleeding.However, too quickly the blood flow recovery can also occur. This is called ischemia-reperfusion trauma when the blood penetrates the tissue, hungry oxygen (a process known as rapper), damaged cells fight to cope, leading to the production of harmful molecules called free radicals that can damage cells, proteins and DNA. This causes additional damage and can cause an inflammatory response.The preliminary study of the Cambridge team showed that when the brain is starving with oxygen, it leads to the accumulation of a chemical called succinate. When the bleeding is restored, the succinate is quickly oxidized to manage the production of free radicals in mitochondria, “batteries” that nourish our cells starting additional damage. This happens in the first few minutes of the rapper, but the researchers have shown that the oxidation of the succinate can be blocked by the molecule of the sparse.“All of this happyns very rapidly, but if we can get malonate in quickly at the start of recordfusion, we can prevent this Oxidation and Burst of Free Radicals. We discovered in our labs that we can get malonate into. Quickly by Lowering the Ph A Little, Making IT A Bit More Acidic Damage, ”Professor Mike Murphy said of the Mitochondrial Biology Department of Medical Studies. Conclusion
A new study found that brain treatment with the form of a chemical known as sodium undercurred (ADSM), as well as mechanical thrombectomy, significantly reduced the amount of brain damage that occurs with an injury of ischemia-reperfusion by as much as 60%.Researchers have developed a mouse model that mimics a mechanical thrombectomy, allowing the team to check the effectiveness of ADSM against ischemia-reperfusion injury.“This approach reduces the number of dead brain tissues as a result of a stroke. This is incredibly important because the amount of dead brain tissue directly correlates with the patient’s recovery, with their disability, whether they can use all their limbs, speak and understand the language, such as Dr. Jordan Lee, doctoral student and one.
Researchers now hope to start clinical tests early.
“If it is successful, the same drug can be much wider for other cases of ischemia-reperfusion injuries such as heart attack, resuscitation, organ transplantation and so on that have similar major mechanisms,” Professor Murphy added.
