Blood sugar fluctuations can have a significant effect on the brain chemistry, contributing to mood swings, irritability and even clinical depression. If the glucose level lowers too low or thorns too high, it can lead to emotional instability, anxiety or feelings “on the edge” for no exact cause. Women may incorrectly make the wrong action of these PMS symptoms, working stress or family problems, but not managed blood sugar may be guilty. Depression is also more common in people with diabetes, creating a bilateral mental and physical health street.